Monday, 31 October 2011

Tecca TV: TechLife on UFO tree hotels, giant Lego men washing ashore, China owning the moon, and more! (Yahoo! News)

Thanks for joining us here at TechLife on Tecca TV, where we give you the 5 best technology-meets-lifestyle news stories in only 5 minutes! We enjoy bringing you a bit of Friday Fun to you each week.

Be sure to peruse the detailed show notes below to find more information on all the stories we covered in this episode. And if you missed our episode last week, be sure to check it out for our take on Android 4.0 (Ice Cream Sandwich), America's first civilian spaceport, the world's most expensive RV, and more.

As always, we would love your feedback on this week's episode of TechLife ? please let us know your thoughts in the comments!

This article originally appeared on Tecca

More from Tecca:

Source: http://us.rd.yahoo.com/dailynews/rss/techblog/*http%3A//news.yahoo.com/s/yblog_technews/20111029/tc_yblog_technews/tecca-tv-techlife-on-ufo-tree-hotels-giant-lego-men-washing-ashore-china-owning-the-moon-and-more

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Nickelodeon airing 'banned' movie on Oct. 31

"Cry Baby Lane," a Nickelodeon movie about conjoined twins who are sawed apart, was deemed so scary after its one airing in October 2000 that it was banned by the network, never to be seen again.

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Or so the story goes.

In fact, both the story in the movie and the story about the movie being banned are urban legends. TeenNick will air the movie on Monday, for the first time in more than a decade, as part of its "Stick-or-Treat" Halloween programming.

A Nickelodeon rep tells TheWrap that "Cry Baby Lane" was never formally banned. It was simply forgotten in the Nick vaults. Recent interest in the movie on Reddit.com, as well as the network's recent success with "The '90s Are That," a revival of its 1990s programming, prompted Nick to add "Baby" to its Halloween night line-up.

The movie will air at midnight and again at 2 a.m. on TeenNick.

"Cry Baby Lane" stars Frank Langella as undertaker Mr. Bennett, who tells brothers Andrew and Carl a creepy story about a local farmer who was the father of conjoined twins. The man was ashamed of the twins ? one good, one evil ? so he kept them locked away. When they died, he sawed them apart and buried them separately.

But when Carl and his pals disturb the grave of the evil twin, bad things happen.

The movie features an early career performance by comedian Jim Gaffigan as a dissatisfied customer of Mr. Bennett's who tries to, ahem, stiff the undertaker on his bill.

Copyright 2011 by TheWrap.com

Source: http://today.msnbc.msn.com/id/45082594/ns/today-entertainment/

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National Grid, others expect power outages for days to come

National Grid and other utility companies are reporting more than 200,000 customers in New York without power after an October snow storm downed power lines in the northeast.

An early taste of winter weather brought down tree limbs all over New York and turned off power for thousands, as wet snow from an unusual October snowstorm meant putting down the rakes and picking up the shovels.

Skip to next paragraph

Around the state, more than 200,000 customers were without power, most in the hard-hit Hudson Valley region of the state. Consolidated Edison reported almost 69,000 customers were without power in Westchester County, as were about 4,700 customers in New York City.

Orange and Rockland said it had 84,000 customers out in Rockland, Orange and Sullivan counties. New York State Electric and Gas reported at least 52,000 customers with outages, and National Grid reported at least 9,300 customers out.

"I think wind is the biggest factor. The wind makes the trees wobbly and they tumble onto our lines and transformers and equipment," said ConEd spokesman Allan Drury. He said it would take several days for full restoration.

In the Hudson Valley, state police evacuated motorists from numerous vehicles stuck on Interstate 84 and the Taconic Parkway overnight and took them to hotels. Police said about 50 to 75 vehicles were towed away so the highways could be plowed, and owners were being reunited with them Sunday afternoon.

The National Weather Service says the storm dropped more than 21 inches of snow in Millbrook in the Hudson Valley. Power was knocked out to more than 110,000 homes and businesses in Dutchess and Ulster counties.

The storm was a taste for what's to come for the demonstrators camping out at Zuccotti Park in lower Manhattan for the Occupy Wall Street protest.

Nick Lemmin, 25, of Brooklyn, spent his first night camping out at the plaza. He slept in a sleeping bag, and had on extra layers ? thermals, a sweatshirt, a scarf.

"I slept actually pretty well," he said. "It was pretty quiet."

He said the OWS demonstrators were prepared for the weather, with tents. "Once you're in a tent, it's pretty warm," he said.

Lemmin thought the early snow was actually helpful, that it gave the protesters a chance to see how cold weather would be before it sets in more permanently.

"I think it's a good test," he said.

Around Albany, where most tree leaves are still green, cottony snow coated every twig and power line Sunday morning. But by noon, under a clear blue sky, the few inches of snowfall had vanished from all but the shadiest grass. At the Occupy Albany encampment across from the Capitol, about 40 people spent the night in tarp-draped tents.

"There was a team of people sweeping snow off tents overnight," said Kathy Manley, who was snug and warm overnight in a winter sleeping bag. "It's getting a little rough with the cold nights, but if people have the proper equipment it's no problem."

A couple of dirt- and leaf-caked snowmen stood among the people waving "We are the 99 percent" signs for passing cars. Geordie O'Brien, sitting with Manley at an information table under a canopy, said the protesters plan to remain in place into the winter.

With temperatures in the 30s on Sunday morning, a brilliant sun shone on Central Park, alive with people taking walks and on exercise runs.

They passed thousands of feet of yellow "caution" tape that kept them away from danger ? downed tree limbs strewn all over the park, ripped off Saturday in the winds that accompanied a record snowfall on New York City.

The damage didn't keep Becky McKee, a visitor from Iowa, from enjoying a unique sight ? Sheep Meadow aglow in snow white against the Manhattan skyline.

"It's so pretty!" exclaimed the teacher's aide from Underwood, Iowa.

"I wasn't expecting to be wearing hat and gloves here," she said.

McKeel said she was impressed by how New Yorkers reacted to Saturday's weather.

"I couldn't believe it. Nothing stops New Yorkers! This is not what I expected," she said.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/jRF_8bgVmt4/National-Grid-others-expect-power-outages-for-days-to-come

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Sunday, 30 October 2011

Five Bucks, Chucked (Balloon Juice)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/155056473?client_source=feed&format=rss

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Life Inc.: Miserable? You don't know history

Scott Grannis/Calafia Beach Pundit

By Allison Linn

The misery index ? a measure of inflation plus unemployment rates?? hit the highest level in nearly three decades last week.

That?s definitely bad news for our pocketbooks, but many of us have experienced much deeper misery.

It turns out we?re still quite a ways from the misery Americans suffered in the mid-1970s and early 1980s, when the index topped out at or near 20, with unemployment of nearly 8 percent and inflation of 12 percent. Last week?s reading was nearly 13, including the 9.1 percent unemployment rate and 3.9 percent year-over-year inflation.

Scott Grannis, a blogger and former chief economist for Western Asset Management, notes that our misery this time around is mostly due to high unemployment ?which is hovering around 9 percent ? although inflation has also recently been on the rise.

Back in the 1970s and 1980s, we were bedeviled by both high unemployment and extremely high inflation, which anyone who tried to buy a house in those years probably remembers well (if not fondly).

Scott Grannis/Calafia Beach Pundit

Of course, that particular trip down memory lane is probably little comfort to the many of us grappling with the current weak economic conditions, and especially to the 14 million people who are unemployed.

?

Related:

Feeling pinched by higher bills, less money? You?re not alone

Older Americans? challenge: Not time to recover from recession

Do you feel more miserable than you did in the 1970s and 1980s?

Source: http://lifeinc.today.msnbc.msn.com/_news/2011/10/27/8510395-good-graph-friday-and-you-thought-you-were-miserable

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Keenum has 9 TD passes, No. 18 Houston beats Rice

Houston quarterback Case Keenum throws a pass during the second half of an NCAA college football game against Rice on Thursday, Oct. 27, 2011, in Houston. Houston won 73-34. (AP Photo/Pat Sullivan)

Houston quarterback Case Keenum throws a pass during the second half of an NCAA college football game against Rice on Thursday, Oct. 27, 2011, in Houston. Houston won 73-34. (AP Photo/Pat Sullivan)

Houston's Jacolby Ashworth (76) and Patrick Edwards (83) celebrate Houston touchdown against Rice during the first half of an NCAA college football game Thursday, Oct. 27, 2011, in Houston. (AP Photo/Pat Sullivan)

A Houston fan tries to stay dry during the first half of Houston's NCAA college football game against Rice on Thursday, Oct. 27, 2011, in Houston. (AP Photo/Pat Sullivan)

Rice running back Turner Petersen, left, is double-teamed by Houston's Nick Saenz (41) and Phillip Steward, center, during the first half of an NCAA college football game Thursday, Oct. 27, 2011, in Houston. (AP Photo/Pat Sullivan)

Houston wide receiver Tyron Carrier (35) loses his helmet as he is tackled by Rice safety Xavier Webb in the first half of an NCAA college football game Thursday, Oct. 27, 2011, in Houston. (AP Photo/Pat Sullivan)

(AP) ? As the clouds rolled in and rain seemed inevitable for Houston's game against Rice on Thursday night, Cougars quarterback Case Keenum told his team he liked playing in the rain.

After he threw an interception and had a fumble returned for a touchdown in the first quarter in heavy rain as Houston fell behind 17-7, he changed his opinion.

"I hate rain games," Keenum said he was thinking. "This is terrible."

Keenum got going after the rain subsided and threw a career-high nine touchdown passes to break the Football Bowl Subdivision record for career TD tosses in the No. 18 Cougars' 73-34 victory.

With the rain at its heaviest, Houston coach Kevin Sumlin expressed his disbelief at the weather.

"I said, 'Surely it's not going to be like this all night. It can't rain like this all night,'" he said. "I guess somebody heard me because it started to stop after that."

After falling behind 17-7, Houston outscored Rice 45-3 to take a 52-20 lead early in the third quarter and cruised to the easy victory to remain undefeated.

Keenum, who became the FBS career leader in total offense last week, has 139 career touchdown passes.

He abused Rice's 115th-ranked defense by throwing TD passes of 57, 21, 64, 18, 41, 20, 37, 22 and 47 yards to break former Texas Tech quarterback Graham Harrell's record of 134.

"It was a blast," Keenum said. "That was probably the most fun I've ever had playing football."

He had so many touchdown passes, he couldn't remember all of them when asked to recount them.

"Maybe if I thought about it, (but) I don't know if I could list them off to you right now," he said.

Patrick Edwards had seven receptions for 318 yards receiving and five touchdowns for Houston (8-0, 4-0 Conference USA).

Tyler Smith had 170 yards rushing and two rushing and one receiving touchdown for Rice (2-6, 1-4). That included a 97-yard scoring run ? the longest TD run in school history.

The Owls led 17-7 late in the first quarter before Keenum threw his first touchdown pass for 57 yards to Edwards. The teams exchanged field goals at the beginning of the second quarter to leave Rice up 20-17.

Keenum then threw three touchdown passes in a 6-minute span at the end of the first half to put Houston on top 38-20 and tie the touchdown passes record.

He broke the record on a 41-yard pass to Charles Sims early in the third quarter to push the lead to 45-20. Keenum smiled and flashed the Cougars hand signal when he appeared on the jumbotron on the sideline.

He was 24 of 37 for 534 yards before giving way to backup Cotton Turner with 8 minutes remaining.

"Those are video-game numbers, something we couldn't get stopped," Rice linebacker Justin Allen said. "The rain slowed down a little bit ... I wished it would have rained all game. It stopped, and they got things cranked up. There was no looking back for them."

Keenum, granted a sixth year of eligibility after tearing a knee ligament early last season, needs 267 yards passing to become the FBS's career leader in passing yards. Former Hawaii star Tim Chang holds the mark of 17,072.

Tyron Carrier tied the NCAA record for career kickoff returns for touchdowns with seven by returning the opening kickoff 100 yards for a score. Carrier dashed down the right sideline and darted around the defense virtually untouched before outrunning the kicker for the score.

Actually, Carrier said no one got a finger on him on the return.

"Not a touch," he said. "That's the way it should be."

He shares the record with former Clemson returner C.J. Spiller.

Carrier also had a touchdown reception, Sims had two and Justin Johnson added one for the Cougars.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-10-28-FBC-T25-Record-Breaking-Keenum/id-1f85032634114094b83583d0df3a7788

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'Jackass' star Bam Margera's Porsche hit in Pa.

(AP) ? Police say a new Porsche driven by "Jackass" star Bam Margera has been sideswiped by another motorist in suburban Philadelphia.

State troopers say there were no injuries or citations issued in Thursday's accident near Margera's home in Pocopson Township.

Margera's mother tells The Philadelphia Inquirer (http://bit.ly/sJR4Mh ) that a truck scraped the length of her son's 4-month-old Panamera while he was stopped at a stop sign.

April Margera says the other driver told Bam that he was looking at his GPS when the crash happened. She says the motorist became excited when he realized who he'd hit.

Margera says her son called home immediately after the accident to get insurance information.

"Jackass" co-star Ryan Dunn and another man died in a drunken driving crash in the area in June.

___

Information from: The Philadelphia Inquirer, http://www.philly.com

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-28-People-Bam%20Margera/id-a7fbac8d44aa4b28bcd549c7cd6aa47e

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Saturday, 29 October 2011

Google paid $151M for Zagat in flurry of 3Q deals (AP)

SAN FRANCISCO ? Google spent more than $500 million to acquire another 27 companies during the third quarter, ensuring this year will be busiest shopping spree in the Internet search leader's history.

The tally emerged Wednesday in a quarterly report that included another previously undisclosed nugget: Google Inc. paid $151 million in cash for the Zagat Survey, a renowned restaurant review publisher that Google bought to counter the popularity of Yelp's business rating service. The price is higher than estimated in previously published reports, which pegged the deal's value between $65 million and $125 million.

Google's latest flurry of deals raised its acquisition count to 57 companies through the first nine months of the year. That already exceeds Google's previous annual record of 48 acquisitions, reached last year.

Although Google has never completed more acquisitions in its 13-year history, the company isn't guaranteed of setting a new spending record.

Through September, Google's deals had cost a total of $1.4 billion. That's below the $1.8 billion that Google spent last year and less than the $3.2 billion it spent in 2008 buying online advertising service DoubleClick, its biggest-ever purchase and its only acquisition that year.

Google agreed to buy cell phone maker for Motorola Mobility Inc. for $12.5 billion in August, but that deal may not be completed before the end of the year. That's because the U.S. Justice Department is investigating whether the proposed takeover would stifle competition in the increasingly important mobile phone market.

Most of Google's acquisitions involve small startups that are developing promising technology or employ talented engineers.

Google snapped up the Zagat Survey because it wanted a well-known brand that would allow it to feature more restaurant recommendations and reviews on its own website instead of sending Web surfers to Yelp and other rivals.

Google tried to buy Yelp in 2009, only to be rebuffed. Yelp is now among a group of competitors trying to convince U.S. regulators that Google has abused its dominance of Internet search by highlighting its own services in its results.

After Zagat, the next-largest acquisition Google completed in the third quarter was the $114 million purchase of Daily Deals, an online discount service in Europe.

Source: http://us.rd.yahoo.com/dailynews/rss/internet/*http%3A//news.yahoo.com/s/ap/20111026/ap_on_hi_te/us_google_acquisitions

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Ryan has backed up big talk, revved up Cowboys' D (AP)

IRVING, Texas ? Within a few days of working for Rob Ryan, the defensive players on the Dallas Cowboys were thrilled with their new boss.

They fed off the energy and excitement he showed in meetings and on the practice field. They were certain his exotic schemes were exactly what was needed to turn the worst defense in franchise history into one of the NFL's best.

Then Ryan did what members of his family do. He shared some of his confidence with reporters.

Tired of hearing about the juggernaut the Philadelphia Eagles were putting together, Ryan said: "I don't know if we win the all-hype team. I think that might have gone to somebody else, but we're going to beat their (rear) when we play them."

While some of his players may have felt that way, too, they weren't about to say it.

"We were like, 'Rob, what the (heck) are you doing?' We don't know you, man. You can't come in here and do that,'" linebacker Bradie James said.

At the time, it seemed as if Ryan was just keeping up the family tradition of talking big, like his twin brother Rex and his dad, Buddy.

Now, with the teams preparing to meet Sunday night, that bulletin-board material looks awfully clever.

Ryan's play-calling and personality has transformed Dallas into the top-ranked defense in the NFC. The Eagles, meanwhile, are 2-4 and looking up at the Cowboys (3-3) and everyone else in the NFC East.

Ryan's early August braggadocio hasn't been forgotten by either team, and is certain to be played up during the national, prime-time broadcast. It adds another layer to a rivalry once fueled by Rob's dad, and to a matchup filled with ramifications for both teams.

"We've got your back," James told Ryan this week, before challenging his boss to make sure the unit is ready for big-play threats Michael Vick, LeSean McCoy and DeSean Jackson.

Ryan's response?

"Shoot yeah! You know I'm up! I'm drinking Red Bulls all night!" James said in a Ryan-esque voice.

Through six games, the Cowboys have adopted the personality of their sideline leader, save for the long, stringy hair and oversized belly.

Using exotic formations and an aggressive mindset, Dallas is allowing the fewest yards rushing in the NFL.

Only five teams allow fewer yards per play. Nobody has scored a touchdown in the first quarter against the Cowboys; they've given up just nine points in the opening period. They also recently held New England to 17 points, shattering the Patriots' streak of 13 straight games with at least 30 points.

And, to think, they're doing this with virtually the same group of guys who last season allowed more points and yards than any of the 50 previous Dallas defenses.

"I give him 100 percent credit," star linebacker DeMarcus Ware said. "He always talks about the players go out there and make the plays, but he gets out there and gives us the opportunity to do that."

The Eagles present a fascinating challenge.

Because of McCoy and Vick, Philadelphia has the top rushing attack in the NFL. The Eagles are also coming off a bye, and coach Andy Reid is 12-0 when given an extra week to prepare for a foe.

Then again, Philadelphia is 0-2 at home and has lost five straight there, counting the playoffs. The Cowboys also have beaten the Eagles in four of the past five meetings, counting the playoffs.

Philadelphia's lone recent win over Dallas included Jackson catching four passes for 210 yards, including a 91-yard touchdown that he punctuated by stopping just shy of the end zone and tipping over the goal line.

That was among many big plays the Cowboys' secondary gave up last season, which is partly why team owner Jerry Jones tried to sign the top free agent cornerback on the market, Nnamdi Asomugha; he went to the Eagles instead, part of the supposed "Dream Team" they were putting together over the summer.

Ryan and Jones were seen on cell phones on the playing field during the negotiations for Asomugha. Everyone saw it, including Terence Newman, the starter who was most likely to have been dumped had a deal been struck.

It's a safe bet that Ryan will have him motivated Sunday.

"If you don't get up playing for Rob, then you just don't have a passion for football," said Mike Jenkins, the other starting cornerback. "He has a lot of confidence on what he has, and that's what builds confidence on the team."

James said the Cowboys have seen ? and heard ? all sorts of things from Ryan this season. They can't help but laugh and keep listening because he's gotten so much out of them.

Even back in early August, James had been around Ryan enough to not be too surprised about what Ryan said about the Eagles. That doesn't mean he liked it.

"I'm like, 'Rob? You picked the Eagles?! C'mon, man, pick St. Louis!'" James said, laughing. "But, here we are. It's time to play ball."

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111028/ap_on_sp_fo_ne/fbn_cowboys_ryan_s_hype

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Research makes it possible to predict how cancers will respond to chemo

Research makes it possible to predict how cancers will respond to chemo [ Back to EurekAlert! ] Public release date: 27-Oct-2011
[ | E-mail | Share Share ]

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

Finding rewrites old theory of why chemo works

BOSTON--Challenging a half-century-old theory about why chemotherapy agents target cancer, scientists at Dana-Farber Cancer Institute have devised a test that can predict how effective the drugs will be by determining whether a patient's tumor cells are already "primed" for death.

In a study published online by the journal Science on Oct. 27, the researchers report that cancer cells that are on the verge of self-destruction are more likely to succumb to certain chemotherapy agents than cancer cells that have yet to reach that stage. The discovery suggests that it may be possible to predict which cancer patients are most likely to benefit from chemotherapy, as well as to make chemotherapy drugs more effective by pushing tumor cells closer to the point of suicide.

"Many chemotherapy agents work by damaging structures within cancer cells, particularly DNA and microtubules [tiny tubes used for a variety of cell functions]," says the study's senior author, Anthony Letai, MD, PhD, of Dana-Farber. "When the damage becomes so extensive it can't be repaired, the cells initiate a process known as apoptosis, in which they sacrifice themselves to avoid passing the damage on to their descendants."

The researchers found that cancer cells that are closer to this apoptotic threshold are more susceptible to chemotherapy than other cancer cells -- and that it's possible to measure how close cells are to that breaking point.

Letai and his colleagues developed a technique called BH3 profiling to make that measurement. The technique focuses on mitochondria -- cell structures where the decision is made whether or not to die -- and proteins known as the BCL-2 family. Within the mitochondria, BCL-2 proteins act like bickering in-laws, some promoting apoptosis, others resisting it. The faction that predominates determines whether the cell lives or embarks on apoptosis.

The measuring technique uses bits of protein known as BH3 peptides from members of the BCL-2 family that spur apoptosis. Scientists prepare cells to allow entry of these BH3 molecules and examine whether holes begin forming in the mitochondria, a key step in apoptosis. A fluorescent dye enables scientists to measure whether the holes are forming. By adding BH3 peptides to the samples and measuring how much was needed to kill the cells, the investigators could gauge how close the cells were to apoptosis. Cells that needed the least BH3 peptide to be nudged into the suicide program were considered primed for death.

In the study, researchers first used the technique in myeloma cells from patients who were about to receive chemotherapy. "We found a high correlation between the cancer cells that were most highly primed and those that were most susceptible to chemotherapy," Letai states. The researchers went on to study tumors from 85 patients -- multiple myelomas, acute myelogenous leukemias, acute lymphoblastic leukemias, and ovarian cancers -- and in each case found the same connection: Chemotherapy proved to be most successful in the tumors that had the greatest mitochondrial priming.

The findings suggest that the conventional wisdom about why cancer chemotherapy works needs to be reconsidered, the study authors say. The traditional explanation -- that chemotherapy targets fast-growing cells such as cancer cells -- has some merit, Letai remarks, but it has never been entirely satisfactory from a scientific viewpoint. For one, there are several types of fast-growing cancers that are not responsive to chemotherapy agents, and several types of slow-growing cancers that are. Moreover, although chemotherapy is notorious for attacking fast-growing normal cells such as the bone marrow and those in the digestive tract, there are many types of cells that turn over rapidly -- such as those in the skin -- that it doesn't harm.

Though widely accepted, Letai says the traditional explanation "was never tested as thoroughly as one would like for something that serves as a linchpin of cancer treatment." The new thinking, while not absolutely refuting the old, indicates the reasons for chemotherapy's success are more complex than generally thought.

The next step for researchers will be to test additional types of cancers to see if the connection between mitochondrial priming and chemotherapy effectiveness is valid for them as well. In addition, Letai's group wants to test in clinical trials whether BH3 profiling can be used to help oncologists better choose therapies for patients.

"One of the goals of personalized medicine is to know, in advance, which agents are likely to be effective in a given patient and which are not," Letai remarks. "This research highlights that potential."

###

The lead authors of the study are Triona Ni Chonghaile, PhD, and Kristopher Sarosiek, PhD, Dana-Farber. Co-authors include: Thanh-Trang Vo, Jeremy Ryan, Anupama Tammareddi, MD, Jing Deng, PhD, Ken Anderson, MD, Paul Richardson, MD, Yu-Tzu Tai, PhD, Constantine Mitsiades, MD, Ursula Matulonis, MD, Ronny Drapkin, MD, PhD, Richard Stone, MD, Daniel DeAngelo, MD, PhD, and Daniel Ruben Carrasco, MD, PhD, Dana-Farber; Stephen Sallan, MD, and Lewis Silverman, MD, Dana-Farber and Children's Hospital Boston; Victoria Del Gaizo Moore, PhD, Elon University, Elon, NC; David McConkey, PhD, MD Anderson Cancer Center, Houston; and Michelle Hirsch, MD, Brigham and Women's Hospital.

Funding for the study was provided by the National Institutes of Health, the Multiple Myeloma Research Foundation, the American Cancer Society, the FLAMES Pan-Massachusetts Challenge Team, and Gabrielle's Angel Foundation for Cancer Research.

Dana-Farber Cancer Institute (http://www.dana-farber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult cancer care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center and it provides pediatric care with Children's Hospital Boston as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Twitter: @danafarber or Facebook: http://www.facebook.com/danafarbercancerinstitute.



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Research makes it possible to predict how cancers will respond to chemo [ Back to EurekAlert! ] Public release date: 27-Oct-2011
[ | E-mail | Share Share ]

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

Finding rewrites old theory of why chemo works

BOSTON--Challenging a half-century-old theory about why chemotherapy agents target cancer, scientists at Dana-Farber Cancer Institute have devised a test that can predict how effective the drugs will be by determining whether a patient's tumor cells are already "primed" for death.

In a study published online by the journal Science on Oct. 27, the researchers report that cancer cells that are on the verge of self-destruction are more likely to succumb to certain chemotherapy agents than cancer cells that have yet to reach that stage. The discovery suggests that it may be possible to predict which cancer patients are most likely to benefit from chemotherapy, as well as to make chemotherapy drugs more effective by pushing tumor cells closer to the point of suicide.

"Many chemotherapy agents work by damaging structures within cancer cells, particularly DNA and microtubules [tiny tubes used for a variety of cell functions]," says the study's senior author, Anthony Letai, MD, PhD, of Dana-Farber. "When the damage becomes so extensive it can't be repaired, the cells initiate a process known as apoptosis, in which they sacrifice themselves to avoid passing the damage on to their descendants."

The researchers found that cancer cells that are closer to this apoptotic threshold are more susceptible to chemotherapy than other cancer cells -- and that it's possible to measure how close cells are to that breaking point.

Letai and his colleagues developed a technique called BH3 profiling to make that measurement. The technique focuses on mitochondria -- cell structures where the decision is made whether or not to die -- and proteins known as the BCL-2 family. Within the mitochondria, BCL-2 proteins act like bickering in-laws, some promoting apoptosis, others resisting it. The faction that predominates determines whether the cell lives or embarks on apoptosis.

The measuring technique uses bits of protein known as BH3 peptides from members of the BCL-2 family that spur apoptosis. Scientists prepare cells to allow entry of these BH3 molecules and examine whether holes begin forming in the mitochondria, a key step in apoptosis. A fluorescent dye enables scientists to measure whether the holes are forming. By adding BH3 peptides to the samples and measuring how much was needed to kill the cells, the investigators could gauge how close the cells were to apoptosis. Cells that needed the least BH3 peptide to be nudged into the suicide program were considered primed for death.

In the study, researchers first used the technique in myeloma cells from patients who were about to receive chemotherapy. "We found a high correlation between the cancer cells that were most highly primed and those that were most susceptible to chemotherapy," Letai states. The researchers went on to study tumors from 85 patients -- multiple myelomas, acute myelogenous leukemias, acute lymphoblastic leukemias, and ovarian cancers -- and in each case found the same connection: Chemotherapy proved to be most successful in the tumors that had the greatest mitochondrial priming.

The findings suggest that the conventional wisdom about why cancer chemotherapy works needs to be reconsidered, the study authors say. The traditional explanation -- that chemotherapy targets fast-growing cells such as cancer cells -- has some merit, Letai remarks, but it has never been entirely satisfactory from a scientific viewpoint. For one, there are several types of fast-growing cancers that are not responsive to chemotherapy agents, and several types of slow-growing cancers that are. Moreover, although chemotherapy is notorious for attacking fast-growing normal cells such as the bone marrow and those in the digestive tract, there are many types of cells that turn over rapidly -- such as those in the skin -- that it doesn't harm.

Though widely accepted, Letai says the traditional explanation "was never tested as thoroughly as one would like for something that serves as a linchpin of cancer treatment." The new thinking, while not absolutely refuting the old, indicates the reasons for chemotherapy's success are more complex than generally thought.

The next step for researchers will be to test additional types of cancers to see if the connection between mitochondrial priming and chemotherapy effectiveness is valid for them as well. In addition, Letai's group wants to test in clinical trials whether BH3 profiling can be used to help oncologists better choose therapies for patients.

"One of the goals of personalized medicine is to know, in advance, which agents are likely to be effective in a given patient and which are not," Letai remarks. "This research highlights that potential."

###

The lead authors of the study are Triona Ni Chonghaile, PhD, and Kristopher Sarosiek, PhD, Dana-Farber. Co-authors include: Thanh-Trang Vo, Jeremy Ryan, Anupama Tammareddi, MD, Jing Deng, PhD, Ken Anderson, MD, Paul Richardson, MD, Yu-Tzu Tai, PhD, Constantine Mitsiades, MD, Ursula Matulonis, MD, Ronny Drapkin, MD, PhD, Richard Stone, MD, Daniel DeAngelo, MD, PhD, and Daniel Ruben Carrasco, MD, PhD, Dana-Farber; Stephen Sallan, MD, and Lewis Silverman, MD, Dana-Farber and Children's Hospital Boston; Victoria Del Gaizo Moore, PhD, Elon University, Elon, NC; David McConkey, PhD, MD Anderson Cancer Center, Houston; and Michelle Hirsch, MD, Brigham and Women's Hospital.

Funding for the study was provided by the National Institutes of Health, the Multiple Myeloma Research Foundation, the American Cancer Society, the FLAMES Pan-Massachusetts Challenge Team, and Gabrielle's Angel Foundation for Cancer Research.

Dana-Farber Cancer Institute (http://www.dana-farber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult cancer care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center and it provides pediatric care with Children's Hospital Boston as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Twitter: @danafarber or Facebook: http://www.facebook.com/danafarbercancerinstitute.



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Source: http://www.eurekalert.org/pub_releases/2011-10/dci-rmi102511.php

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Friday, 28 October 2011

Corning's 3Q profit rises 3 percent (AP)

ROCHESTER, N.Y. ? Corning Inc. said Wednesday its profit rose 3 percent in the third quarter, lifted by surging sales of optical fiber and glass for flat-panel televisions, smartphones and touch-screen tablets.

The results handily beat Wall Street expectations, and the specialty glass maker signaled that U.S. retail demand for liquid-crystal-display TVs has gathered pace in recent months and South Korean TV-panel makers are boosting glass production in the current quarter.

Its shares rose 23 cents, or 1.7 percent, to $13.95 in midday trading after rising as high as $14.94 earlier in the session. The stock has ranged from $11.51 to $23.43 in the past year.

While worldwide demand for LCD TVs is up 20 percent this year, previously sluggish U.S. sales climbed 10 percent in July and August and 13 percent in September, "which is actually the strongest growth rate we've seen all year," said Chief Financial Officer Jim Flaws.

"And for the first two weeks of October, sales in the U.S. are up 13 percent," Flaws said in a conference call with analysts.

The world's largest maker of LCD glass with more than 60 percent of the global market, Corning reported net income of $811 million, or 51 cents per share, in the July-September period. That's up from $785 million, or 50 cents per share, a year earlier.

Excluding special items, adjusted earnings were 48 cents per share. That was well above Wall Street expectations of 42 cents per share.

Revenue jumped 30 percent to $2.08 billion from $1.6 billion. Analysts expected $2.03 billion.

Sales of LCD glass bounded 26 percent higher in the quarter to $815 million, and sales of the telecommunications unit rose 21 percent to $560 million. Corning also saw double-digit growth in its other three units ? Gorilla cover glass, auto-pollution filters and research labware.

In recent quarters, a soft economy has been cutting into U.S. demand for flat-screen televisions and, as a result, for the glass that Corning makes. But the company did better in glass production this summer than it projected in early September.

Volume in its wholly owned business increased in the mid-single digits compared with the second quarter and fell more than 20 percent in its joint venture with South Korea's Samsung Electronics. The combined total glass volume fell about 10 percent sequentially.

However, Corning had warned that it expected volume in its wholly owned business to be level with the second quarter and volume in its joint venture to drop 30 percent.

"It's obviously a difficult economic environment and we're dealing with a difficult contraction in the supply chain in the second half," Flaws said. "But I'd remind people we're on pace to reach" a record $7.9 billion in sales this year and $10 billion by 2014.

DisplaySearch estimates 206 million LCD-TVs will be shipped worldwide in 2011, up 7.5 percent from 2010. But in North America, shipments are expected to fall 2 percent to 37.5 million units. Three months ago, the market-research firm from Austin, Texas, projected a 2.6 percent rise in North American shipments.

In the United States and western Europe, "the persistence of the recession is causing people to continue to focus" on low-end LCD-TVs even as manufacturers push "higher-end models that have step-up features," said DisplaySearch analyst Paul Gagnon.

"That is causing people to either look away from the TV market for a little while or wait for prices to get better, or perhaps spend those dollars on other hot consumer electronics categories ... like tablets and smartphones."

In contrast, growth seen in emerging markets such as China, India and Eastern Europe is expected to remain vigorous as shoppers swap traditional cathode-ray-tube TVs for LCD TVs, Gagnon said.

Propelled by ultra-strong Gorilla glass, which is now migrating from handheld and tablet devices to high-end TVs, specialty materials revenue swelled almost 90 percent to $299 million.

Three months ago, Corning lowered its 2011 sales forecast for Gorilla to $800 million from $1 billion. Invented in 1962, Gorilla found commercial use only in 2008 and sales surged to $250 million in 2010.

Environmental technologies revenue jumped 19 percent to $247 million, driven by robust demand for auto-pollution filters.

Life-sciences revenue rose 22 percent to $153 million, reflecting Corning's acquisition of Axygen BioScience Inc. as it shifts beyond a heavy focus on display glass. It bought the maker of plastic labware and liquid handling products for research labs for about $400 million in September 2009.

Surging revenue in Corning's telecommunications unit was driven by a more than 30 percent increase in higher demand for fiber-to-the-home products in North America and Europe.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20111026/ap_on_hi_te/us_earns_corning

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Somalia, Libya, Uganda: US increases Africa focus

FILE - In this Wednesday, April 20, 2011 file photo, U.S. Army soldiers are seen with Uganda People's Defence Force soldiers at the closing ceremony for operation ATLAS DROP 11, an annual joint aerial delivery exercise, in Soroti, about 400 kilometers east of Uganda's capital city Kampala. While putting few U.S. troops at risk, the United States is providing intelligence and training to fight militants across the continent, from Mauritania in the west along the Atlantic Ocean, to Somalia in the east along the Indian Ocean. (AP Photo/Stephen Wandera, File)

FILE - In this Wednesday, April 20, 2011 file photo, U.S. Army soldiers are seen with Uganda People's Defence Force soldiers at the closing ceremony for operation ATLAS DROP 11, an annual joint aerial delivery exercise, in Soroti, about 400 kilometers east of Uganda's capital city Kampala. While putting few U.S. troops at risk, the United States is providing intelligence and training to fight militants across the continent, from Mauritania in the west along the Atlantic Ocean, to Somalia in the east along the Indian Ocean. (AP Photo/Stephen Wandera, File)

FILE - In this Monday, May 10, 2010 file photo, Malian special forces listen to instructions from a U.S. Special Forces soldier on counter-ambush tactics in Kita, Mali, during a joint training exercise. While putting few U.S. troops at risk, the United States is providing intelligence and training to fight militants across the continent, from Mauritania in the west along the Atlantic Ocean, to Somalia in the east along the Indian Ocean. (AP Photo/Alfred de Montesquiou, File)

FILE - In this Monday, May 10, 2010 file photo, Malian special forces drill to face off an ambush as a U.S. Special Forces soldier gives instructions from a Malian truck in Kita, Mali, during a joint training exercise. While putting few U.S. troops at risk, the United States is providing intelligence and training to fight militants across the continent, from Mauritania in the west along the Atlantic Ocean, to Somalia in the east along the Indian Ocean. (AP Photo/Alfred de Montesquiou, File)

FILE - In a March 24, 1994 file photo, U.S. soldiers board a C-5 transport plane bound for Dover Air Force Base in Delaware, at Mogadishu, as the U.S. military's presence in Somalia winds down. By the time U.S. military forces left Somalia in 1994 after entering the lawless nation more than a year earlier to stop a famine, 44 Army soldiers, Marines and airmen had been killed and dozens more wounded. But the U.S. has come back, using special forces advisers, drones and tens of millions of dollars in military aid to combat a growing and multifaceted security threat. (AP Photo/John Moore, File)

FILE - In this May 11, 2011 file photo, American-born Islamist militant fighter Omar Hamammi, known as Abu Mansur Al-Amriki, right, and deputy leader of al-Shabab Sheik Mukhtar Abu Mansur Robow, left, sit under a banner which reads "Allah is Great" during a news conference at a farm in southern Mogadishu's Afgoye district. After leaving Somalia in 1994, the United States has come back, this time in a less obtrusive role but focusing once again on Somalia. U.S. and European officials are especially worried that an al-Qaida group known as AQIM is working to establish contacts with Boko Haram and al-Shabab, the Islamist Somali insurgent group that has recruited dozens of Americans. (AP Photo/Farah Abdi Warsameh, File)

(AP) ? While putting few U.S. troops at risk, the United States is playing a growing role in Africa's military battles, using special forces advisers, drones and tens of millions of dollars in military aid to combat a growing and multifaceted security threat.

Once again, the focus is Somalia, the lawless nation that was the site of America's last large-scale military intervention in Africa in the early 1990s. By the time U.S. forces departed, 44 Army soldiers, Marines and airmen had been killed and dozens more wounded.

This time the United States is playing a less visible role, providing intelligence and training to fight militants across the continent, from Mauritania in the west along the Atlantic coast, to Somalia in the east along the Indian Ocean.

The renewed focus on Africa follows a series of recent and dramatic attacks.

In August, a hard-line Islamist group in Nigeria known as Boko Haram bombed the U.N. headquarters in the capital, Abuja, killing 23 people. A year earlier, militants from the Somali group al-Shabab unleashed twin bombings in Kampala, Uganda, that killed 76. And a Nigerian man tried to blow up an airliner over Detroit on Christmas Day 2009 during a flight that originated from Lagos, Nigeria.

Most worrisome to the United States is al-Shabab, an al-Qaida-linked group in Somalia that has recruited dozens of Americans, most of Somali descent.

"If you ask me what keeps me awake at night, it is the thought of an American passport-holding person who transits through a training camp in Somalia and gets some skill and then finds their way back into the United States to attack Americans," Gen. Carter Ham, the commander of the U.S. Africa Command, said in Washington this month. "That's mission failure for us."

U.S. and European officials also worry that AQIM ? an al-Qaida group that operates in the west and north of Africa ? is working to establish links with Boko Haram and al-Shabab, the Somali insurgent group.

"I think the security threats emanating from Africa are being taken more seriously than they have been before, and they're more real," said Jennifer Cooke, the director of the Africa program at the Washington-based Center for Strategic and International Studies.

The U.S. is conducting counterterrorism training and equipping militaries in countries including Algeria, Burkina Faso, Chad, Mali, Mauritania, Morocco, Niger, Nigeria, Senegal and Tunisia to "preclude terrorists from establishing sanctuaries," according to the U.S. Africa Command.

In Somalia, the U.S. helps support 9,000 troops from Uganda and Burundi to fight militants in Mogadishu, the Somali capital. In June, the Pentagon moved to send nearly $45 million in military equipment, including four drones, body armor and night-vision and communications gear, for use in the fight against al-Shabab.

The U.S. also announced this month it is sending 100 advisers, most of them special forces, to help direct the fight against the rebel Lord's Resistance Army in Central Africa and efforts to kill or capture its leader, Joseph Kony, who is wanted by the International Criminal Court. In Libya, U.S. fighter planes helped rebels defeat former dictator Moammar Gadhafi.

In the latest attack against Africa's militants, Kenya deployed troops this month into southern Somalia to fight al-Shabab insurgents. The U.S. says it is not aiding Kenya's incursion, but America has given Kenya $24 million in aid this year "to counter terrorists and participate in peacekeeping operations," the U.S. Embassy said.

The U.S. government "has had a burr under its saddle about Somalia" for years, dating to the 1993 downing of two U.S. helicopters over Mogadishu in a battle that became known as Black Hawk Down, said John Pike of the Globalsecurity.org think tank near Washington. Eighteen U.S. troops were killed.

At that time, Washington had deployed thousands of troops to combat a famine, but the mission escalated into a hunt for warlords.

These days, only a handful of U.S. troops are involved directly in Somalia ? special forces troops who enter on kill missions. In 2009, Navy SEALs targeted and killed al-Qaida operative Saleh Ali Saleh Nabhan in a helicopter raid. The Americans jumped out of the helicopters, grabbed Nabhan's body from his bullet-riddled convoy and flew off. The corpse ? like Osama bin Laden's two years later ? was buried at sea.

Pike, who monitors defense issues, said the Pentagon has ramped up operations in Africa tremendously since the time of former Defense Secretary Donald Rumsfeld, who didn't see Africa as being in America's strategic interest.

"The U.S. has really developed an interest in Africa that we just have never seen before," Pike said.

"Between all the goings and comings in the Horn of Africa and all this snake-eater (special forces) Sahara stuff ... it's all over the place," Pike said. "Since I think an awful lot of it is being run out of Special Operations Command and out of (the CIA), I think it probably far larger than anyone imagines."

U.S. drones launched from the Seychelles islands in the Indian Ocean also provide intelligence, and the pilotless planes are capable of being armed.

Al-Shabab counts 31 American citizens among its ranks, a U.S. official in Washington told The Associated Press. They're mostly American-Somalis who left the U.S. to join the group. The U.S. official, who spoke on condition of anonymity to discuss sensitive intelligence matters, said foreign fighters among al-Shabab's ranks want to attack Western targets.

Intelligence has revealed sophisticated plans by al-Shabab to attack targets in Europe, the official said, but the operations have been disrupted by the recent stepped-up fighting in Somalia.

Ugandan and Burundian troops fighting al-Shabab militants in Mogadishu as part of an African Union force have pushed back the insurgents in recent months and now control most of the capital. The Kenyan incursion has forced al-Shabab to fight on its southern flank as well.

Though the Kenyan invasion appears to further the U.S. goal of pressuring al-Shabab, U.S. officials say the American military is not providing assistance.

"The United States has supported Kenyan efforts to improve its ability to monitor and control often porous land and maritime borders and territory exploited by terrorists and illicit traffickers, particularly along its border with Somalia," said Katya Thomas, a spokeswoman at the U.S. Embassy in Nairobi.

But, she added: "The United States did not encourage the Kenyan government to act, nor did Kenya seek our views. We note that Kenya has a right to defend itself against threats to its security and its citizens."

Some aspects of Kenya's military adventure appear poorly thought out. Troops moved in just as seasonal rains began and are now bogged down in the mud ? a literal reminder of the potential quagmire for countries that intervene in Somalia, whose last nationwide leader was overthrown in 1991.

A paper published by the U.S. Army examining the ill-fated U.S. mission in Somalia in the 1990s concluded that "the chaotic political situation of that unhappy land bogged down U.S. and allied forces in what became, in effect, a poorly organized United Nations nation-building operation."

It was a 2006 invasion of Somalia by Ethiopia that gave rise to the militants now known as al-Shabab.

"That's the problem with Somalia, there is just no easy answer," said Cooke, the analyst. "The problem is so huge and multi-faceted that tackling one aspect of it, i.e., beating back al-Shabab, just can't fix it. Part of the problem is that the government we have invested in as our key partner in Somalia is a fiction of a government, and so Kenya can try to create some space, but there is nothing to fill that."

The chairman of the Pentagon's Joint Chiefs of Staff, Gen. Martin E. Dempsey, told the House Armed Services Committee this month that the U.S. must remain active in Africa because terrorists are networked globally.

"One of the places they sit is Pakistan. One of the places they sit is Afghanistan. One of the places they sit is the African continent," Dempsey said.

___

Associated Press reporter Lolita Baldor in Washington contributed to this report.

___

Online: http://www.history.army.mil/brochures/somalia/somalia.htm

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-10-27-AF-Africa-US-Military/id-50d45b44b7234d8db0ae9821de0d465c

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Wiz Khalifa, Snoop Dogg's 'High School' Soundtrack A 'Big Deal'

'I'm a fan of it, separate myself from making it. ... Can't wait,' Wiz tells Mixtape Daily.
By Rob Markman


Snoop Dogg and Wiz Khalifa
Photo: MTV News

The O.D.: A Mixtape Exclusive

Sure, Wiz Khalifa was only 5 years old when Snoop Dogg first stepped onto the scene as a guest on Dr. Dre's 1992 classic "Deep Cover," but the two cannabis-loving MCs won't let their respective ages get in the way of collaboration. Wiz and Snoop will star alongside each other in the upcoming Dylan Brown-directed stoner comedy "Mac and Devin Go to High School" as well as on its smoked-out soundtrack.

Mixtape Daily caught up with the Doggfather and Khalifa on the set for "Young, Wild and Free," the soundtrack's official first single, and got the scoop on the rest of the LP.

"We got the homey Juicy J on the soundtrack, we got Curren$y on the soundtrack, but mainly it's just me and Dogg," Wiz revealed. Overall, Khalifa is just hyped up to work with one of his idols. They linked on Wiz's "Black & Yellow" remix, Snoop's "This Weed Iz Mine," as well as a bunch of underground songs like "That Good" and "French Inhale."

"It's a real big deal because nobody's done it like that as far as a veteran in the game, an OG, a pioneer and then the newest, youngest, most exciting dude in rap coming through and really just giving people a complete project," Wiz said. "I'm a fan of it, separate myself from making it, [I'm] a huge fan of it. Can't wait." As far as the musical vibe of the soundtrack, a laidback Snoop tried his best to describe it. "It's something to relax you and get you through the day; it's some real good music. The music is quality, I don't even have no title for it, as far as what kinda music is it, it's centric, it's ...," Dogg said searching for the right words before his partner-in-rhyme lent a hand. "Eclectic," Wiz chimed in.

"Yeah, that's probably what it is," Snoop finished.

For other artists featured in Mixtape Daily, check out Mixtape Daily Headlines.

Related Artists

Source: http://www.mtv.com/news/articles/1673119/wiz-khalifa-snoop-dogg-high-school-soundtrack.jhtml

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Stocks end higher on reports of help for Europe

Specialist Dermot Bermingham, left, and trader Kevin Lodewick, work on the floor of the New York Stock Exchange Wednesday, Oct. 26, 2011. (AP Photo/Richard Drew)

Specialist Dermot Bermingham, left, and trader Kevin Lodewick, work on the floor of the New York Stock Exchange Wednesday, Oct. 26, 2011. (AP Photo/Richard Drew)

(AP) ? Stock indexes finished higher Wednesday following reports that China will come to the aid of Europe by investing in a financial rescue fund.

Agence France-Presse reported that China has agreed to invest in Europe's financial rescue fund, which will be used to support struggling countries and banks in the European Union. The Dow Jones industrial average jumped more than 100 points after the report came out in the early afternoon.

Stocks had been mixed for much of the day as investors weighed stronger earnings from Boeing and Corning with uncertainty about the outcome of a key meeting among European leaders.

Top European officials met in Brussels to discuss how to contain the region's debt crisis, which has festered for two years. One consideration is increasing the power of a financial rescue fund, which Germany's parliament approved shortly before U.S. stock markets opened.

European officials announced a plan after the U.S. market closed that will require the region's banks to increase their levels of cash to better protect themselves from losses on the Greek bonds they hold. European governments have been pressing the banks to forgive significant amounts of the Greek government's debt.

"This is a total news and rumor-driven market right now, and everyone's attention is focused on Europe," said Joe Bell, an analyst at Schaeffer's Investment Research.

The Dow Jones industrial average gained 162.42 points, or 1.4 percent, to 11,869.04. Boeing Co. led the way. It rose 4.5 percent after it reported a bigger profit for its latest quarter than analysts expected. It also raised its forecast for 2011 earnings.

The S&P 500 index rose 12.95, or 1.1 percent, to 1,242. The Nasdaq composite added 12.25, or 0.5 percent, to 2,650.67. Amazon.com Inc. slumped 12.7 percent after reporting a 73 percent drop in income. The retailer cited higher costs for expansion.

Strong economic reports also helped send stocks higher. Businesses ordered more heavy machinery and other long-lasting manufactured goods last month, after excluding aircraft orders, which can be volatile. That indicates businesses are still spending on equipment despite worries about a weak economy and Europe's debt problems. Sales of new homes rose in September after falling for four straight months. Lower home prices enticed buyers.

The yield on the 10-year Treasury note rose to 2.21 percent from 2.14 percent late Tuesday as demand diminished for assets perceived to be relatively safe.

Corning Inc. rose 3 percent after reporting a 3 percent increase in income last quarter on stronger sales of glass for flat-panel televisions. Its earnings and revenue beat analysts' expectations.

First Solar Inc. rose 6.6 percent. It reported results a week earlier than expected, and revenue and earnings both improved. That helped the stock recover some of its losses from Tuesday, when it fell 24 percent after the surprise departure of the company's chief executive.

Five stocks rose for every one that fell on the New York Stock Exchange. Volume was slightly above average at 4.8 billion shares.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-10-26-Wall%20Street/id-a93fa582b4294ee2a56043a876793fe7

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Thursday, 27 October 2011

Book ?em, Chuck-o: Liddell on ?Hawaii Five-O? tonight

UFC Hall-of-Famer Chuck Liddell continues his retirement that does not involve starting a vineyard tonight on CBS. He'll play the difficult role of "mixed martial artist" on the episode that airs at 10 p.m. ET. Pro Elite provided both the cage for the episode and this behind-the-scenes shot.

Book ?em, Chuck-o: Liddell on ?Hawaii Five-O? tonight

As you can see, this role will truly stretch his acting chops. Tonight's episode will be a about "a wealthy restaurant owner is murdered and the investigation leads McGarrett to take part in a charity mixed martial arts fight."

According to IMDB, Liddell has several acting credits to his name, including spots on "Criminal Minds," "Blade: The Series," and "How High," where he played a tough guy. Apparently, he also served as a transportation coordinator for "Hollywood's Magical Island: Catalina" in 2003.

Source: http://sports.yahoo.com/mma/blog/cagewriter/post/Book-em-Chuck-o-Liddell-on-Hawaii-Five-O-to?urn=mma-wp8491

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Rosette Wins Loebner Prize 2011

mikejuk writes "Bruce Wilcox won the First Prize of $4000 and the Bronze Annual Medal in the 21st Loebner Prize Competition held in the UK at the University of Exeter on October 19, 2011 with his new chatbot, Rosette. If you would like to chat to Rosette you can at TellTaleGames. If you have been following the run up to this year's competition you may be surprised at how poorly CleverBot performed given its track record. This chatbot, which searches through earlier conversations for its answers, had received a score of 59.3% in a test that took place in India in September in which humans were rated 63.3%, only 4 percentage points higher and was also featured in a video that went viral. However its developer entered a cutdown version of CleverBot into the Loebner prize selection round and it didn't get the chance to show off its prowess in the final. So we will have to wait for another year to see if it really is as good as it claims." Depending on your bent, you may agree with Unknown Lamer that this sounds less impressive when phrased as "fooling a person ~18 percent of the time." I think that's a pretty high number, myself!

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/Lwz2hDj2wpQ/rosette-wins-loebner-prize-2011

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Wednesday, 26 October 2011

Tenth Tibetan monk burns self in west China: group (Reuters)

BEIJING (Reuters) ? A Tibetan Buddhist monk doused himself in fuel and set himself ablaze in far western China on Tuesday, the tenth ethnic Tibetan this year to resort to the extreme form of protest, an overseas advocacy group said.

The Free Tibet group said the latest self-immolation happened outside a monastery in Ganzi in Sichuan province, about 150 km (95 miles) south of Aba, the site of eight of the last nine self-immolations since March to protest against religious controls imposed by the Chinese government.

In a statement emailed late Tuesday, Free Tibet said it had no information about the monk's name, whereabouts, or whether he survived the incident.

Nor did it specify its sources.

Government officials, police and workers at several hotels in Ganzi, called Kandze by Tibetans, told Reuters they did not know about the reported self-immolation.

"I don't know about this, and even if I did, I couldn't be loose-lipped," said an official in the Ganzi county office.

Most people in Ganzi and neighboring Aba are ethnic Tibetan herders and farmers, and many see themselves as members of a wider Tibetan region encompassing the official Tibetan Autonomous Region and other areas across the vast highlands of China's west.

The string of self-immolations, at least five of them fatal, "represents a wider rejection of China's occupation of Tibet," said Stephanie Brigden, the director of Free Tibet, which campaigns for self-rule for the region.

The group reported "significantly increased numbers of security personnel including in Tibet's capital, Lhasa, hundreds of kilometers away from where the self-immolations have taken place."

For the Chinese government, the protests are a small but destabilizing challenge to its regional policies, which it says have lifted Tibetans out of poverty and servitude.

China has ruled what it calls the Tibet Autonomous Region since Communist troops marched in 1950. It rejects criticisms of rights groups and exiled Tibetans and has condemned the self-immolations as destructive and immoral.

In March 2008, protests and deadly riots against the Chinese presence spread across Tibetan regions, triggering sometimes deadly confrontations with troops and police.

Tibet's exiled spiritual leader, the Dalai Lama, who China condemns as a supporter of violent separatism for his homeland, last week led hundreds of maroon-robed monks, nuns and lay Tibetans in prayer to mourn those who have burned themselves to death or been imprisoned.

The Dalai Lama denies advocating violence and insists he wants only real autonomy for his homeland, from which he fled in 1959 after a failed uprising against Chinese rule.

But the Chinese Foreign Ministry has said the Dalai Lama should take the blame for the burnings, and repeated Beijing's line that Tibetans are free to practice their Buddhist faith.

(Reporting by Chris Buckley and Sabrina Mao; Editing by Paul Tait)

Source: http://us.rd.yahoo.com/dailynews/rss/china/*http%3A//news.yahoo.com/s/nm/20111026/wl_nm/us_china_tibet

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